Late Appearance of Hyperlipemia in Hypopituitarism

Article1 October 1961Late Appearance of Hyperlipemia in HypopituitarismDAVID R. JACOBS, M.D., DOROTHY T. KRIEGER, M.D., RENE N. CHARLES, M.D.DAVID R. JACOBS, M.D.Search for more papers by this author, DOROTHY T. KRIEGER, M.D.Search for more papers by this author, RENE N. CHARLES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-640 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPituitary insufficiency is rarely reported to exist in association with an abnormal elevation in the serum triglycerides. In those instances where the two conditions have coexisted, except for the diabetic hyperlipemia occurring with acromegaly, attempts to attribute the lipid abnormality to a specific endocrine or metabolic defect were not usually made (1, 2). However, Tabatznik and Rabinowitz (3) demonstrated that the hyperlipemia in their hypopituitary patient, as well as in one described by Zollner (4), was reversible once the associated myxedema was corrected.The present report describes the appearance of unexplained hyperlipemia in three patients with pre-existing hypopituitarism. In two...References1. SMITHHOWARD CWRP: Variations in endocrine gland function in post-partum pituitary necrosis. J. Clin. Endocr. 19: 1420, 1959. CrossrefGoogle Scholar2. WILLIAMS RH: Textbook of Endocrinology, 2d Ed., W. B. Saunders Co., Philadelphia, 1956, p. 64. Google Scholar3. TABATZNIKRABINOWITZ BD: Hyperglyceridemia and lipemia retinalis in hypopituitarism. Bull. Johns Hopkins Hosp. 107: 175, 1960. MedlineGoogle Scholar4. ZOLLNER N: Hypopituitarismus (Sheehansches Syndrom) mit Hyperlipamie und Xanthomen. Deutsch. Med. Wschr. 80: 999, 1955, as cited in reference no. 3. CrossrefMedlineGoogle Scholar5. 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CHARLES, M.D.Affiliations: New York, New YorkReceived for publication April 26, 1961.From the Endocrine Research Laboratory and Clinic and the Nutrition Research Laboratory of the Department of Medicine, and the Department of Chemistry, The Mount Sinai Hospital, New York, N. Y.Requests for reprints should be addressed to David R. Jacobs, M.D., Department of Medicine, The Mount Sinai Hospital, Fifth Avenue and 100th Street, New York 29, N. Y. 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