Key result
Pulmonary endarterectomy and conduit exchange successfully treated chronic thromboembolic pulmonary hypertension secondary to ePTFE valved pulmonary conduit thrombosis, improving pulmonary vascular resistance from 2.3 to 0.89 WU.
Why the study?
There is no consensus on the preferred conduit for right ventricular outflow tract reconstruction for congenital cardiac disease.
Case Report (n=1)
Thrombosis of an ePTFE valved pulmonary conduit can lead to CTEPH and warrants conduit exchange at the time of pulmonary thromboendarterectomy.
Hypothesis-generating for conduit exchange during endarterectomy in thrombosis-related CTEPH; prospective studies needed before practice change.
BACKGROUND: There is no consensus on the preferred conduit for right ventricular outflow tract (RVOT) reconstruction for congenital cardiac disease. CASE SUMMARY: We present a case of a 21-year-old woman with history of tetralogy of Fallot presenting with recurrent graft thrombosis and pulmonary emboli in the setting of RVOT reconstruction with a 20-mm expanded polytetrafluoroethylene (ePTFE) valved conduit (GORE PV1, W.L. Gore & Associates). A diagnosis of chronic thromboembolic pulmonary hypertension was made, and the patient underwent pulmonary endarterectomy and conduit exchange with a pulmonary homograft. DISCUSSION: The novelty and clinical significance of this report lies in the confirmation of thrombosis of a large-diameter ePTFE valved pulmonary conduit (20 mm) and its implications for monitoring and need for further optimization of thromboprophylaxis strategies in this population.
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Robinson et al. (2025) conducted a case report in Chronic thromboembolic pulmonary hypertension (n=1). Pulmonary endarterectomy and conduit exchange was evaluated on Improvement in pulmonary hemodynamics and symptoms. Pulmonary endarterectomy and conduit exchange successfully treated chronic thromboembolic pulmonary hypertension secondary to ePTFE valved pulmonary conduit thrombosis, improving pulmonary vascular resistance from 2.3 to 0.89 WU.
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