Key result
Ossification of the posterior longitudinal ligament was associated with a significantly increased risk of acute myocardial infarction compared to matched controls (adjusted HR 2.209).
Why the study?
The study aimed to investigate the relationship between acute myocardial infarction and ossification of the posterior longitudinal ligament in Korea.
Does ossification of the posterior longitudinal ligament increase the risk of acute myocardial infarction in adults?
Cohort (n=7,734)
Does ossification of the posterior longitudinal ligament increase the risk of acute myocardial infarction in adults?
Hazard Ratio: 2.209 (95% CI 1.311–3.721)
Absolute Event Rate: 2.044% vs 1.135%
p-value: p=0.003
Patients with ossification of the posterior longitudinal ligament have a significantly higher risk of developing acute myocardial infarction, particularly among younger women without traditional cardiovascular risk factors.
Objective: This nationally matched longitudinal study aimed to investigate the relationship between acute myocardial infarction (AMI) and ossification of the posterior longitudinal ligament (OPLL) in Korea.Methods: We collected patient data from January 1, 2004 to December 31, 2015 from the National Health Insurance Service Health Screening Cohort. Patients with OPLL were defined as patients with the International Classification of Diseases, Tenth Revision code M48.8 (other specified spondylopathies) and were newly diagnosed through computed tomography imaging. The OPLL group had a total of 1,289 patients. The control group included 6,445 people. Utilizing the Kaplan-Meier technique, The incidence of AMI in both groups was estimated. A Cox proportional-hazards regression analysis was used to compute the AMI hazard ratio.Results: After controlling for age and sex, the hazard ratio of AMI in the OPLL group was 2.065 (95% confidence interval [CI], 1.228-3.474). The adjusted hazard ratio in the OPLL group was 2.209 after restricting the sample for demographics and concomitant medical conditions (95% CI, 1.311-3.721). In a subgroup analysis, the incidence of AMI was substantially greater in the OPLL group, which included women younger than 65 years and without hypertension, diabetes, or dyslipidemia.Conclusion: This nationwide longitudinal study found that patients with OPLL were at higher risk of AMI.
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Kim et al. (2023) conducted a cohort in Ossification of the posterior longitudinal ligament (OPLL) (n=7,734). Ossification of the posterior longitudinal ligament (OPLL) vs. Matched controls without OPLL was evaluated on Incidence of acute myocardial infarction (AMI) (HR 2.209, 95% CI 1.311-3.721, p=0.003). Ossification of the posterior longitudinal ligament was associated with a significantly increased risk of acute myocardial infarction compared to matched controls (adjusted HR 2.209).
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