Key result
Maternal plasma adenosine deaminase activity was significantly higher in women who conceived a fetus with central nervous system malformations compared to normal pregnancies (12.3 vs 3.3 U/L; P<0.05).
Why the study?
Is maternal plasma adenosine deaminase (ADA) activity elevated in women who have conceived a fetus with central nervous system malformations compared to normal pregnancies?
Case-Control (n=136)
Is maternal plasma adenosine deaminase (ADA) activity elevated in women who have conceived a fetus with central nervous system malformations compared to normal pregnancies?
Maternal plasma ADA activity is significantly elevated in pregnancies with fetal CNS malformations, suggesting potential utility as a biomarker.
Elevated maternal ADA was associated with fetal CNS malformations; leaves open biomarker utility pending prospective validation.
OBJECTIVE: To establish the adenosine deaminase (ADA) activity in women who had been pregnant with a child suffering from central nervous system (CNS) anomaly. METHODS: The study group comprised 68 women who had been pregnant with an affected child, and 68 controls matched for age, gestational age and body mass index. Maternal venous blood was collected for measurement of ADA levels. We defined the diagnostic sensitivity, specificity and area under receiver-operating characteristic curve for ADA. RESULTS: Plasma ADA activity was significantly higher in the study group (12.3 U/L, range 1.7-33.3) compared to the median value of 3.3 U/L (range 1.1-34.4) in normal pregnancies (P<0.05). The cut-off point of ADA >5.9 U/L was associated with the highest combination of specificity (58.8%) and sensitivity (86.8%). CONCLUSION: ADA activity in women who have conceived a fetus with CNS malformations was significantly higher than that in normal pregnant women.
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Üstün et al. (2007) conducted a case-control in Fetal central nervous system malformations (n=136). Pregnancy with a fetus with central nervous system malformations vs. Normal pregnancies was evaluated on Plasma adenosine deaminase (ADA) activity (p=<0.05). Maternal plasma adenosine deaminase activity was significantly higher in women who conceived a fetus with central nervous system malformations compared to normal pregnancies (12.3 vs 3.3 U/L; P<0.05).
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