Key result
Serum sST2 levels did not differ significantly between healthy cats and cats with asymptomatic or symptomatic cardiomyopathy, although they positively correlated with left atrial diameter.
Why the study?
Soluble ST2 is a novel biomarker of mechanical stress linked to cardiac hypertrophy, fibrosis, and ventricular dysfunction, but its levels in cats with cardiomyopathy needed evaluation.
Does serum sST2 level correlate with the severity of cardiomyopathy and other cardiac biomarkers in cats?
Cross-Sectional (n=24)
No
Does serum sST2 level correlate with the severity of cardiomyopathy and other cardiac biomarkers in cats?
In cats with cardiomyopathy, serum sST2 levels did not significantly differ by disease severity stage, though they correlated positively with left atrial diameter and CK-MB.
sST2 should not guide cardiomyopathy staging in cats; leaves open its biomarker utility pending prospective studies.
Soluble suppression of tumorigenesis-2 (sST2), a member of the interleukin-1 receptor family, is a novel biomarker of mechanical stress that is measurable in serum. It has been shown in humans and animals to be physiologically related to cardiac hypertrophy, fibrosis, and ventricular dysfunction. This study aimed to evaluate sST2 levels in cats with cardiomyopathy. In addition, serum sST2 and other cardiac biomarker levels were compared. Twenty-four client-owned cats with hypertrophic cardiomyopathy (HCM) and restrictive cardiomyopathy (RCM) were investigated. The cats included in the study were divided into four groups (I, II, III, and IV) according to the American College of Veterinary Internal Medicine (ACVIM) classification. Class B1 cats were included in group I (n=7), class B2 cats were included in group II (n=6), class C cats were included in group III (n=6), and healthy control-group cats in group IV (n=5). Measurement of cardiac troponin I (cTnI), cardiac troponin T (cTnT), N-terminal pro-brain natriuretic peptide (NT-proBNP), creatine kinase-MB (CK-MB), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), sST2 levels, and echocardiographic examinations were performed in all groups, and correlations were investigated. We observed positive correlations among sST2 levels and CK-MB and LA diameter (p=0.05). There was no correlation between sST2, NT-proBNP, Troponin I, Troponin T, AST, and LDH levels. We confirmed positive correlations between NT-proBNP levels and LA diameter (p<0.05), CK-MB, IVSd, LVFWd, and LA/Ao ratio (p<0.01). Cardiac biomarkers have diagnostic significance for feline cardiomyopathies. There was no statistically significant difference in sST2 levels between the groups. However, further research is needed to investigate the relationship between the severity of cardiomyopathies and sST2 levels in cats.
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Kaya et al. (2022) conducted a cross-sectional in Cardiomyopathy (n=24). Cardiomyopathy vs. Healthy controls was evaluated on Serum sST2 levels (p=0.407). Serum sST2 levels did not differ significantly between healthy cats and cats with asymptomatic or symptomatic cardiomyopathy, although they positively correlated with left atrial diameter.
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