Why the study?
Does perfusion of high or low calcium solutions alter surface and intracellular electrograms in the in situ canine heart?
Does perfusion of high or low calcium solutions alter surface and intracellular electrograms in the in situ canine heart?
True S-T segment elevation can be caused by faster repolarization of cardiac muscle cells in the injured area, as demonstrated by high calcium perfusion in a canine model.
Answers are grounded in this paper and cite their sources.
High calcium may induce true ST elevation via repolarization changes in canine injury; hypothesis-generating for human ECG mechanisms and requires clinical validation.
Effects of calcium on myocardial cells were investigated in the in situ canine heart. Ninety-three experiments were performed on 28 anesthetized dogs. Solutions of high or low calcium concentrations were perfused into the coronary artery through an artificial coronary circuit. Surface and intracellular electrograms were simultaneously recorded. The most prominent effect of low calcium was the prolongation of the membrane action potential duration. The most prominent effects of high calcium were a shortening or disappearance of phase 2 and a decrease in the amplitude of phase 2. The mechanism of S-T segment elevation is discussed in association with these findings. These observations show that true S-T segment elevation can be caused by the faster repolarization of cardiac muscle cells in the injured area.
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Prinzmetal et al. (1970) studied this question.
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