Key result
Administration of multiple doses of naloxone for opioid overdose induced noncardiogenic pulmonary edema in a 62-year-old female, which resolved with diuretics and oxygen supplementation.
Why the study?
Naloxone-induced noncardiogenic pulmonary edema is a rare but reported complication following naloxone use in opioid overdose reversal, appearing more common with higher doses.
Case Report (n=1)
No
Naloxone administration for opioid overdose can rarely cause noncardiogenic pulmonary edema, highlighting the need for careful airway management and use of the lowest effective dose.
May warrant vigilance for pulmonary edema after repeated naloxone; single case leaves open dose-risk causality for further study.
Naloxone-induced noncardiogenic pulmonary edema is a rare but reported entity that can occur following naloxone use in the reversal of opioid overdose. Proposed mechanisms include an adrenergic crisis secondary to catecholamine surge which causes more volume shift to pulmonary vasculature, subsequently leading to pulmonary edema. It appears to be more common when higher doses of naloxone are used. We present a case of a patient with opioid overdose came with altered mental status developed early features of pulmonary edema following the administration of multiple doses of naloxone. She responded well with the administration of diuretics and oxygen supplementation. Her oxygen requirements improved and didn't require mechanical ventilation.
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Elkattawy et al. (2021) conducted a case report in Opioid overdose (n=1). Naloxone was evaluated on Development of pulmonary edema. Administration of multiple doses of naloxone for opioid overdose induced noncardiogenic pulmonary edema in a 62-year-old female, which resolved with diuretics and oxygen supplementation.
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