The propagation of influenza A (PR 8 strain) and Newcastle disease virus in the bovine mammary gland led to the presence in milk and blood serum of neutralizing antibody. The removal of the gland had a profound effect upon the antibody content of the blood. It is suggested that the major portion of antibody was produced locally in the gland. Whether this results from continuous antigenic stimulation or is a function developed from a fleeting contact with the virus remains unanswered.
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Mitchell et al. (1956) studied this question.