Key result
β1-selective beta-blocker usage in postmenopausal women was associated with significantly higher L1-4 and L2-4 bone mineral density (P=0.015 and P=0.025, respectively) compared to controls.
Why the study?
Discerning the effects of sympatholytic beta-1-selective beta-blockers on bone health is of great clinical importance.
Does β1-selective beta-blocker use improve bone mineral density and reduce fracture risk in postmenopausal women?
Observational (n=60)
Does β1-selective beta-blocker use improve bone mineral density and reduce fracture risk in postmenopausal women?
The use of β1-selective beta-blockers is associated with higher lumbar bone mineral density in postmenopausal women.
Answers are grounded in this paper and cite their sources.
β1-selective beta-blocker use was associated with higher lumbar BMD; hypothesis-generating for fracture prevention, needs prospective confirmation.
Background/aim: β1-selective beta-blockers (BBs) are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of β1-selective BBs on bone mineral density (BMD) and fracture risk. Materials and methods: This study included postmenopausal women who used β1-selective BBs (BB group) and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool (FRAX). Results: A total of 60 participants were included in the study. L1-4 and L2-4 BMD values were significantly higher in BB group than control group (P = 0.015 and P = 0.025, respectively). Moreover, T-scores of lumbar and femur total were significantly higher in the BB group. Two patients in BB and 6 patients in control group had previous fragility fracture. No statistically significant intergroup difference was noted regarding FRAX. Conclusion: Based on our results, β1-selective BB usage was associated with higher BMD at the lumbar region in postmenopausal women.
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Keleş et al. (2020) conducted an observational in Postmenopausal bone health (n=60). β1-selective beta-blockers vs. Control group (no β1-selective beta-blockers) was evaluated on Bone mineral density (BMD) and fracture risk (p=0.015). β1-selective beta-blocker usage in postmenopausal women was associated with significantly higher L1-4 and L2-4 bone mineral density (P=0.015 and P=0.025, respectively) compared to controls.
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