Key result
Protamine has evolved from its discovery in heritability experiments to its use in insulin formulations, heparin neutralization in cardiothoracic surgery, and recently, gene therapy.
This historical review details the journey of protamine from its discovery in heritability experiments to its critical role in heparin neutralization and emerging applications in gene therapy.
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Historical review contextualizes protamine's heparin role; leaves open gene therapy applications.
Jecko Thachil (2021) reported a review. Protamine was evaluated. Protamine has evolved from its discovery in heritability experiments to its use in insulin formulations, heparin neutralization in cardiothoracic surgery, and recently, gene therapy.
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