A mathematical model of the batch acetone‐butanol fermentation has been proposed which reflects the process kinetics and biochemistry. The degree of importance of the key kinetic parameters has been established by a parametric sensitivity analysis. The basic model was further extended by incorporating additional culture physiological parameters such as the number of active mass transport sites and the permeability of the cellular membrane as well as the intracellular and extracellular conditions. The model assisted in studying the role of the cellular membrane in the control of the culture performance and solvent biosynthesis. The theoretical predictions were confirmed by experimental results.
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Yerushalmi et al. (1986) studied this question.
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