Application of polynuclear metal clusters for phasing X-ray crystal structures of macromolecules is discussed. Their strong isomorphous and anomalous scattering signal is particularly useful for phasing structures of large macromolecules and complexes, especially at low resolution. The popularity of the metal clusters in macromolecular crystallography is expected to grow in the future. .
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Zbigniew Dauter (2005) studied this question.
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