Carcinogenic activity of smoke condensate from cigarettes with ammonium sulfamate-treated paper

The carcinogenic activities of smoke condensates from experimental cigarettes, the paper of which had been treated with ammonium sulfamate (AS), were compared on mouse skin with the activities of condensates from untreated control cigarettes in two tests. During most of the test periods, the tars from the experimental cigarettes produced significantly fewer tumors than those from the controls; toward the end, these differences decreased, and the differences in final tumor incidence were not statistically significant. The time course of tumor development, however, did differ significantly (p < 0.05), and implied a reduction in cocarcinogen concentration.