Key result
In children and adolescents with cystic fibrosis and reduced pulmonary function (FEV1<60%), minimum SpO2 during sleep was significantly correlated with the HRV LF/HF index (r=0.71; p=0.02).
Why the study?
The study was conducted to evaluate whether sleep disorders are associated with heart rate variability findings in children and adolescents with cystic fibrosis.
Are sleep disorders associated with altered heart rate variability in children and adolescents with cystic fibrosis?
Cross-Sectional (n=30)
Are sleep disorders associated with altered heart rate variability in children and adolescents with cystic fibrosis?
Sleep disorders, particularly nocturnal hypoxemia, are correlated with altered autonomic nervous system modulation (HRV) in children and adolescents with cystic fibrosis, especially those with reduced pulmonary function.
OBJECTIVE: To assess the association of sleep disorders with the findings of heart rate variability (HRV) in children and adolescents with cystic fibrosis (CF). METHODS: Cross-sectional study including children and adolescents aged six to 18 years with a clinical diagnosis of CF. Sociodemographic and clinical data were collected. Sleep disorders were evaluated using baseline nocturnal polysomnography. The autonomic nervous system (ANS) was evaluated through resting HRV. RESULTS: A total of 30 individuals (11.2 years) with a mean forced expiratory volume in the first second (FEV1) of 62.7% were included. The respiratory disturbance index presented a median of 2.6 and obstructive sleep apnea syndrome (OSAS) was identified in 30%. In the HRV analysis, a mean standard deviation of all inter-beat (RR) intervals (SDNN) of 60.8±45.9ms was found. There was a significant correlation between the HRV low-frequency/high-frequency (LF/HF) global modulation index and the minimum SpO2 during sleep in patients with FEV1<60% (r=0.71; p=0.02). The prevalence of sleep disorders and HRV abnormalities was higher in individuals with lesser pulmonary function (FEV1<60%). CONCLUSIONS: The results indicate a weak correlation of sleep disorders (minimum SpO2) with HRV parameters (LH/HF) in children and adolescents with CF. When pulmonary function was reduced, a stronger correlation was found, highlighting the influence of disease severity. A high prevalence of ANS disorders, nocturnal hypoxemia, and presence of OSAS was also found.
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Lugão et al. (2021) conducted a cross-sectional in cystic fibrosis (n=30). Sleep disorders (minimum SpO2 during sleep) was evaluated on correlation between the HRV low-frequency/high-frequency (LF/HF) global modulation index and the minimum SpO2 during sleep in patients with FEV1<60% (r=0.71, p=0.02). In children and adolescents with cystic fibrosis and reduced pulmonary function (FEV1<60%), minimum SpO2 during sleep was significantly correlated with the HRV LF/HF index (r=0.71; p=0.02).
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