Key result
Percutaneous closure of ventricular septal defects significantly reduced left ventricular Z-score from 1.53 to 0.31 (p=0.0001) and left atrial Z-score from 2.78 to 1.54 (p=0.0001) within one month.
Why the study?
While surgery is the gold standard for hemodynamically significant ventricular septal defects, transcatheter closure has emerged as an option in selected cases, warranting evaluation of its clinical outcomes and effects on echocardiographic left-sided chamber parameters.
Does percutaneous closure of VSD improve symptoms and reduce left-sided chamber volume overload in patients with VSD?
Cross-Sectional (n=38)
No
Does percutaneous closure of VSD improve symptoms and reduce left-sided chamber volume overload in patients with VSD?
Percutaneous closure of VSD is safe and effective, leading to rapid normalization of left ventricular and left atrial sizes and improvement in heart failure symptoms.
Answers are grounded in this paper and cite their sources.
May reduce left chamber sizes after percutaneous VSD closure in selected cases; leaves open need for randomized trials.
Background: Ventricular septal defects (VSD) are the most common congenital cardiac anomalies. Hemodynamically significant defects require closure. Surgery is the gold standard for most defects. Recently, transcatheter closure has provided an acceptable option in selected cases. We aim to evaluate the outcomes of percutaneous closure of VSD and assess the effect of device closure on echocardiographic left-sided chamber parameters.
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Iyad AL Ammouri (2023) conducted a cross-sectional in Ventricular septal defects (n=38). Percutaneous closure of ventricular septal defects vs. Baseline (pre-procedure) was evaluated on Left ventricular Z-score at 1 month (p=0.0001). Percutaneous closure of ventricular septal defects significantly reduced left ventricular Z-score from 1.53 to 0.31 (p=0.0001) and left atrial Z-score from 2.78 to 1.54 (p=0.0001) within one month.
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