Infectious Disease: A Cause of Hemolytic Anemia in Glucose-6 Phosphate Dehydrogenase Deficiency

Editorials1 January 1969Infectious Disease: A Cause of Hemolytic Anemia in Glucose-6 Phosphate Dehydrogenase DeficiencyEDWARD R. BURKA, M.D., F.A.C.P.EDWARD R. BURKA, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-1-222 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe role played by a congenital deficiency of the erythrocyte enzyme glucose-6 phosphate dehydrogenase (G6PD) in drug-induced hemolytic anemias has received increasing attention in both the medical literature and the public press (1). The defect is transmitted as a sex-linked trait, hemizygous males and homozygous females being fully affected, and heterozygous females having a partial deficiency of the enzyme (2). With an estimated 13% of American Negro males affected (2, 3), the magnitude of the problem is indicated by the fact that in the United States alone there are at least 1 million affected persons. Clinical problems in enzyme-deficient individuals...References1. LYONS RD: Lack of enzyme linked to anemia, in The New York Times, vol. 117, 40408, p. 10, September 11 1968. Google Scholar2. MARKS PA: Glucose-6 phosphate dehydrogenase: its properties and role in mature erythrocytes, in The Red Blood Cell, edited by HARRIS, J. W., Academic Press, Inc., Publishers, New York, 1964, pp. 211-241. Google Scholar3. BURKAWEAVERMARKS ERZPA: Clinical spectrum of hemolytic anemia associated with glucose-6 phosphate dehydrogenase deficiency. Ann. Intern. Med. 64: 817, 1966. LinkGoogle Scholar4. CARSONFLANAGANICKESALVING PECLCEAS: Enzymatic deficiency in primaquine-sensitive erythrocytes. Science 124: 484, 1956. CrossrefMedlineGoogle Scholar5. TARLOVBREWERCARSONALVING ARGJPEAS: Primaquine sensitivity. Glucose-6-phosphate dehydrogenase deficiency: an inborn error of metabolism of medical and biological significance. Arch. Intern. Med. (Chicago) 109: 209, 1962. CrossrefMedlineGoogle Scholar6. PHILLIPSSILVERS SMNP: Glucose-6 phosphate dehydrogenase deficiency, infectious hepatitis, acute hemolysis, and renal failure. Ann. Intern. Med. 70: 99, 1969. LinkGoogle Scholar7. SALENGOLDSTEINHAURANIWIRTS GFFCW: Acute hemolytic anemia complicating viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency. Ann. Intern. Med. 65: 1210, 1966. LinkGoogle Scholar8. NECHELESGORSTEIN TFD: Virus-induced hemolysis in erythrocytes deficient in glucose-6 phosphate dehydrogenase. Science 160: 536, 1968. CrossrefGoogle Scholar9. JACOBJANDL HSJH: A simple visual screening test for glucose-6 phosphate dehydrogenase deficiency employing ascorbate and cyanide. New Eng. J. Med. 274: 1162, 1966. CrossrefMedlineGoogle Scholar10. MARKS PA: in The Genetics of Migrant and Isolate Populations, edited by GOLDSCHMIDT, E., The Williams & Wilkins Co., Baltimore, 1963, p. 75. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedications and Glucose-6-Phosphate Dehydrogenase DeficiencyIncreased incidence of sepsis and altered monocyte functions in severely injured type A− glucose-6-phosphate dehydrogenase-deficient African American trauma patientsTransient inhibition of glucose utilization by erythrocytes during the acute stage of typhoid feverChemical toxicity of red cells.GLUCOSE–6–PHOSPHATE DEHYDROGENASE DEFICIENCY IN PAPUA NEW GUINEA USING A SIMPLE METHYLENE BLUE REDUCTION TESTG-6-PD hemolytic anemiacomplicating diabetic ketoacidosis 1 January 1969Volume 70, Issue 1Page: 222-225KeywordsDehydrogenasesDrugsEnzymesHemolytic anemiaInfectious diseasesPhosphates Issue Published: 1 January 1969 PDF downloadLoading ...