Cell mediated gene therapy: A guide for doctors in the clinic

The recent approval of gene therapy products in Europe and Asia and the upsurge of gene therapy products in clinical trials signal the rebound of this technology not only for many orphan diseases but also for non­life threatening diseases. Following the success of induced pluripotent stem (iPS) cells in research, other modified ex vivo gene therapies are also knocking on the door of the clinic. Historically, gene therapy has experienced many ups and downs and still faces many challenges. REVIEW Submit a Manuscript: http://www.wjgnet.com/esps/ Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx DOI: 10.5496/wjmg.v5.i1.1 World J Med Genet 2015 February 27; 5(1): 1-13 ISSN 2220-3184 (online) © 2015 Baishideng Publishing Group Inc. All rights reserved. World Journal of Medical Genetics W J M G February 27, 2015|Volume 5|Issue 1| WJMG|www.wjgnet.com 1 clinic. This is the right time for the physicians to have knowledge of this evolving technology that already reached the bedside. Noh MJ, Copeland O, O’Mara M, Lee KH. Cell mediated gene therapy: A guide for doctors in the clinic. World J Med Genet 2015; 5(1): 1-13 Available from: URL: http://www.wjgnet. com/2220-3184/full/v5/i1/1.htm DOI: http://dx.doi.org/10.5496/ wjmg.v5.i1.1