Key result
LMNA mutations were identified in 21 carriers across 3 families, causing a progressive, age-dependent form of dilated cardiomyopathy with conduction system disease and high mortality.
Population
31 unrelated patients with dilated cardiomyopathy and conduction system disease, and their family members.
Design
Cohort
Authors
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May support LMNA screening in familial DCM with conduction disease; leaves open prospective validation of monitoring protocols.
Observational (n=31)
Genetic screening in familial DCM with conduction system disease identifies presymptomatic LMNA mutation carriers who require close monitoring due to age-dependent progression to heart failure and sudden death.
Perrot et al. (2006) conducted an observational in Dilated cardiomyopathy with conduction system disease (n=31). LMNA gene mutations was evaluated on Identification of LMNA mutations and phenotypic disease manifestation. LMNA mutations were identified in 21 carriers across 3 families, causing a progressive, age-dependent form of dilated cardiomyopathy with conduction system disease and high mortality.
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