⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

July 1, 2008Antimicrobial Agents and ChemotherapyOpen Access

Effects of Subinhibitory Concentrations of Antibiotics on SOS and DNA Repair Gene Expression in Staphylococcus aureus

Lili Rosana Mesak Vivian Miao Julian Davies

View Full Paper

Ask AI

Bookmark

Share

Abstract

Reporter clones of Staphylococcus aureus with different SOS response- and DNA repair-associated promoter-lux gene fusion constructs were constructed to study the effects of sub-MICs of antibiotics on the transcription of the SOS and methyl mismatch repair (MMR) genes. Fluoroquinolones (FQs) upmodulated both the SOS and the MMR genes. The patterns of antibiotic-induced transcriptional modulation were altered in FQ-resistant mutants.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Mesak et al. (2008) studied this question.

synapsesocial.com/papers/6a98d28d7a0bd180b0e10bc9 https://doi.org/10.1128/aac.01599-07

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Subinhibitory cerulenin inhibits staphylococcal exoprotein production by blocking transcription rather than by blocking secretionOriginal Research · 2005 · 23 citations
2Characterization of the <i>Staphylococcus aureus</i> Heat Shock, Cold Shock, Stringent, and SOS Responses and Their Effects on Log-Phase mRNA TurnoverOriginal Research · 2006 · 275 citations
3Expression of lux Genes in a Clinical Isolate of Streptococcus pneumoniae : Using Bioluminescence To Monitor Gemifloxacin ActivityOriginal Research · 2002 · 58 citations
4A RecA-LexA-dependent Pathway Mediates Ciprofloxacin-induced Fibronectin Binding in Staphylococcus aureusOriginal Research · 2004 · 84 citations
5Cefodizime: effects of sub-inhibitory concentrations on adhesiveness and bacterial morphology of Staphylococcus aureus and Escherichia coli: comparison with cefotaxime and ceftriaxoneOriginal Research · 1997 · 29 citations

More related papers

Complete and SOS-Mediated Response of <i>Staphylococcus aureus</i> to the Antibiotic Ciprofloxacin2006
Induction and Inhibition of Ciprofloxacin Resistance-Conferring Mutations in Hypermutator Bacteria2005
Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid2002

More from Antimicrobial Agents and Chemotherapy

Activity of oral β-lactams, tebipenem and ceftibuten, combined with novel oral β-lactamase inhibitors against broad-spectrum β-lactamase-producing Escherichia coliWed,
Rifampicin-resistant Staphylococcus epidermidis implant-associated infections: the therapeutic potential of ceftaroline and daptomycin combinationsWed,