Population
Canine aortic strips and COS-7 cells expressing cloned canine AT1 angiotensin II receptor
Design
Preclinical
Authors
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May limit translation of canine AT1 findings to humans; leaves open the structural role of residue 163 in antagonist affinity.
The cloning of the canine AT1 receptor reveals that its low affinity for the antagonist DuP753 is likely due to a specific amino acid substitution (threonine at position 163) compared to other mammalian receptors.
Burns et al. (1994) studied this question.
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