Acetonuria and the Relation of Acetone to "Acid Intoxication"

This protective device I have found very practical and useful in all cases of contusions received at the ends of fingers and toes, as well as after amputations of these members.Particularly will the guard be '"<' intestines reaches the liver by direct route in ¡Is most; concentrated form and its destructive action, if I"1)', would be exerted on the liver.Acetone is excreted '.v the lungs and kidneys, where again it would be con- CeÜtrated and exert its deleterious action if any.In "' ''ord with this idea are the experiments of Embdon, jjjinkowski, von Schroeder and others, which showed ,|;<' liver to be the principal seat of acetone, that the synthetic processes that change aniinonia into urea, etc., hike place in the liver and that the appearance of large T'untities of ammonia in the urine is due to disturbed llV('i' function.Acetone is a thin colorless fluid with a peculiar fruit- d<e odor and belongs to a class of compounds produced ¡y incomplete Oxidation of secondary alcohols.It will dissolve fat, resins and dehydrate tissues, having such Powerful dehydrating properties that in using the '!'''lone method for paraffin sections, the water from ,lsh tissue can be entirely extracted within twenty ''"mîtes, thus allowing direct transfer to paraffin, acetone and its associates, diaeelic and oxybufyric acids.'J'e possibly being constantly formed in minute ipianli- ,'"s in normal metabolism, although, unfortunately, it la ' ?'uipossihle to détermine (his accurately.In certain Weases some of the intermediate products of catabolism ' ';"illv ';) appeal' in the urine, especially in such acute P°nditions as acute yellow atrophy, phosphorus poisonii)':' '""I acute toxemias, in all of which there is rapid