Hematological, biochemical and histopathological changes in Caspian brown trout ( Salmo trutta caspius Kessler, 1877) following exposure to sublethal concentrations of chlorpyrifos

The main objective of this study was to survey the acute and sublethal effect of chlorpyrifos (CPF) on Caspian brown trout (Salmo trutta caspius). Toxicity tests were performed for the determination of 96 h median lethal concentration (96hLC50). For this purpose, nominal concentrations of CPF including 0.0125, 0.025, 0.05, 0.1, 0.2 and 0.3 mgL− 1. The 96hLC50 value of CPF was 0.026 mgL−1. The sublethal effect was determined on the basis of acute toxicity, hematological effects, biochemical plasma profile, behavioral and histopathological changes. The experimental group exposed to CPF at nominal concentration of 0.0026 mgL−1 (10% 96hLC50) for 30 days showed significant changes in hematological and biochemical profiles and caused histopathological changes in liver, gill and kidney. Based on these data, CPF is acute toxic for Caspian trout.