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November 1, 1992Journal of the American Chemical Society

Contribution to the development of new substitution patterns of optically active .beta.-lactams: synthesis of homochiral 4-(1-aminoalkyl)azetidin-2-ones from N-(tert-butyloxycarbonyl) .alpha.-amino aldehyde-derived imines via asymmetric Staudinger reaction

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Authors

CPClaudio PalomoUniversity of the Basque CountryFCFernando P. CossíoDonostia International Physics CenterCCCarmen CuevasPharmaMar (Spain)

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Overview

New route to homochiral 4-(1-aminoalkyl)azetidin-2-ones; extends asymmetric Staudinger methodology but leaves open broader applications.

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Palomo et al. (1992) studied this question.

synapsesocial.com/papers/6a98deb2e8ca4d2af6362525https://doi.org/10.1021/ja00050a016
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