Most successful reactions carried out under continuous flow conditions mix homogeneous solutions yielding homogeneous products. Using solids is avoided to prevent pump and reactor clogging; even though solid reagents may often be the best choice for a given transformation. Here we demonstrate that by pumping aldehydes, ketones, or in situ formed imines through a specially formulated NaBH 4 column results in efficient reductions. The column design and performance characteristics, along with substrate scope, are discussed.
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Gilmore et al. (2014) studied this question.
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