Optically pure 2-oxoindolinyl-β 3,3 -amino esters were obtained in good yields via highly efficient diastereoselective asymmetric Reformatsky-type reaction of isatin-derived chiral N -sulfinyl ketimines. The method is practical and allows rapid access to various important synthetic intermediates such as N -free 2-oxoindolinyl-β 3,3 -amino acid, spiro-β-lactam, and hexahydrofurano[2,3- b ]indole. It can also be used for the synthesis of gastrin/cholecyctokinin-B receptor antagonist AG-041R.
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Xu et al. (2016) studied this question.