Key result
Recombinant caspase 3 caused myofibril degradation and hydrolysed myofibril proteins under conditions similar to those found in muscle during the post mortem conditioning period.
Population
Myofibrils isolated from porcine longissimus dorsi muscle (LD)
Comparison
Full-length human recombinant caspase 3 (rC3) vs Varying concentrations, temperatures, and…
Design
Preclinical
Follow-up
up to 5 days
Authors
Loading...
Caspase-3 may mediate post-mortem myofibril breakdown in porcine muscle; leaves open any role in human myopathies or therapeutics.
Recombinant caspase 3 degrades porcine skeletal muscle myofibrillar proteins under post-mortem conditions, indicating a potential role in meat tenderization.
Kemp et al. (2008) studied Meat tenderisation (porcine skeletal muscle). Recombinant caspase 3 (rC3) was evaluated on Myofibril protein degradation. Recombinant caspase 3 caused myofibril degradation and hydrolysed myofibril proteins under conditions similar to those found in muscle during the post mortem conditioning period.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: