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September 2, 2026Experimental Hematology and OncologyOpen Access

Clinical outcomes and molecular features of CEBPA-mutated MPAL: a multi-center case series

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Authors

YWYirong WuWLWeijie LuoNANa An

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Overview

Multicenter case series observes high mortality without transplantation in CEBPA-mutated mixed phenotype acute leukemia, suggesting this mutation does not confer favorable prognosis as seen in AML.

Key Points

  • To assess the clinical outcomes and molecular characteristics of CEBPA-mutated mixed phenotype acute leukemia.
  • Retrospective multicenter case series of eight patients (N=8) with CEBPA-mutated MPAL treated across five Chinese centers.
  • Evaluated molecular profiles, including biallelic inactivation and bZIP domain mutations, alongside survival outcomes stratified by allogeneic hematopoietic stem cell transplantation (allo-HSCT).
  • All four patients receiving allo-HSCT in first complete remission remained alive and relapse-free at a median follow-up of 24.0 months.
  • Three of the four non-transplanted patients died, with one having refractory disease and two experiencing relapse.
  • Biallelic inactivation occurred in four patients and bZIP mutations occurred in six patients, without conferring the favorable prognosis typically observed in AML.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a98e3bf52d74751e81ff211https://doi.org/10.1186/s40164-026-00823-y
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