Key result
The SA 14-14-2 live-attenuated Japanese encephalitis vaccine demonstrated 43.8% effectiveness (95% CI 1.9-67.8) based on records and 72.2% based on history or records against JE in Indian children.
Why the study?
Does a single subcutaneous dose of Japanese encephalitis SA 14-14-2 live-attenuated vaccine prevent laboratory-confirmed Japanese encephalitis in Indian children aged 1-15 years?
Case-Control (n=745)
Yes
Does a single subcutaneous dose of Japanese encephalitis SA 14-14-2 live-attenuated vaccine prevent laboratory-confirmed Japanese encephalitis in Indian children aged 1-15 years?
A single subcutaneous dose of the SA 14-14-2 JE vaccine provides moderate effectiveness against Japanese encephalitis in Indian children.
Answers are grounded in this paper and cite their sources.
Supports moderate VE of single-dose JE vaccine in Indian children; leaves open confirmation by prospective trials.
OBJECTIVES: We estimate the effectiveness of Japanese encephalitis (JE) SA 14-14-2 live-attenuated vaccination single dose campaign among children aged 1-15 years in India during 2006-07. METHODS: Acute encephalitis syndrome (AES) cases hospitalized following vaccination campaigns during the years 2006-08 were investigated retrospectively. The laboratory-confirmed JE cases were detected from the surveillance laboratories based on anti-JE IgM antibody by ELISA or viral RNA detection by RT-PCR in sera or cerebrospinal fluid. Consent was sought from parents or guardians. Four community controls were chosen randomly per case during house-to-house survey employing individual matching on age, gender and residence during the risk period. Vaccination history was enquired from the child's guardian and verified from vaccination card at home or records at health centre. Conditional logistic regression was conducted on matched case-control sets. RESULTS: We studied 149 cases and matched 596 controls. Vaccination effectiveness was 43.8% (95% CI, 1.9-67.8) based on vaccination card or record. However, effectiveness was 72.2% (95% CI, 56.2-82.4) based on parental history or card/record. Vaccination effectiveness in Assam state was higher than in Uttar Pradesh state. CONCLUSIONS: We concluded that the single subcutaneous dose of SA 14-14-2 JE vaccine provided moderate effectiveness in Indian children.
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Tandale et al. (2018) conducted a case-control in Japanese encephalitis (n=745). SA 14-14-2 live-attenuated Japanese encephalitis vaccine vs. Unvaccinated was evaluated on Vaccination effectiveness (Vaccination effectiveness 43.8%, 95% CI 1.9-67.8). The SA 14-14-2 live-attenuated Japanese encephalitis vaccine demonstrated 43.8% effectiveness (95% CI 1.9-67.8) based on records and 72.2% based on history or records against JE in Indian children.
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