Key result
Surgical resection and chemo/radiotherapy were utilized in two cases of primary cardiac synovial sarcoma, though both patients ultimately died from disease progression at 1.5 years and 32 months.
Case Report (n=2)
No
Complete surgical resection combined with chemo/radiotherapy is the standard approach for rare cardiac synovial sarcomas, with total artificial heart implantation as a potential bridge to transplant in selected cases.
Multimodal therapy remains standard for cardiac synovial sarcoma; case reports leave open TAH bridging utility.
BACKGROUND: Primary heart sarcomas are exceedingly rare tumors. Among primary cardiac sarcomas, synovial sarcoma is one of the rarest, involving cardiac cavities or pericardium. CASE PRESENTATION: Two cases of synovial sarcoma are presented with the clinical course and therapy. Both cases were treated with surgery and chemo/radiotherapy. Interestingly, one of the patient, a 52-year-old male with an intracardiac synovial sarcoma, undergone a SynCardia total artificial heart implantation, but died for multiple pulmonary metastases waiting for transplantation. CONCLUSION: Complete surgical resection of cardiac synovial sarcoma is the gold standard of therapy, though rarely possible. Although guidelines for the treatment are not well established, due to limited number of cases reported, chemotherapy and radiotherapy are frequently administered and seem to prolong mean patient's survival. Cardiac transplantation could be considered in selected cases.
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Coli et al. (2018) conducted a case report in Primary cardiac synovial sarcoma (n=2). Surgical resection and chemo/radiotherapy was evaluated on Clinical course and survival. Surgical resection and chemo/radiotherapy were utilized in two cases of primary cardiac synovial sarcoma, though both patients ultimately died from disease progression at 1.5 years and 32 months.
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