Key result
Age-related macular degeneration in men was associated with significantly higher serum levels of hsCRP (6.96 vs 3.64 mg/l, P<0.0001) and ET-1 (0.66 vs 0.52 pg/ml, P=0.025) compared to healthy controls.
Why the study?
Are serum levels of hsCRP and ET-1 elevated in male patients with age-related macular degeneration compared to healthy controls?
Case-Control (n=93)
Are serum levels of hsCRP and ET-1 elevated in male patients with age-related macular degeneration compared to healthy controls?
Absolute Event Rate: 6.96% vs 3.64%
p-value: p=<0.0001
Serum levels of hsCRP and ET-1 are significantly elevated in male patients with age-related macular degeneration, suggesting a potential association with inflammation and endothelial dysfunction.
Background: Age-related macular degeneration (AMD) is the most common cause of elderly irreversible vision loss in the world. Since C-reactive protein (CRP) is a potential risk factor that has been known to induce AMD, this study was designed to explore the relationship between AMD and serum levels of high sensitivity C-reactive protein (hsCRP), and endothelin-1 (ET-1). Methods The subjects were 48 males with AMD (28 with wet type and 20 with dry type) having a mean age of 69.4 ± 9.6 years and a matched group of 45 apparently healthy control subjects. The AMD was diagnosed using a slit-lamp with super filled lens, fundus photography and fluorescein angiography. Levels of hsCRP and ET-1 were determined using ELISA methods. Results: hsCRP (6.96 ± 5.15 vs. 3.64 ± 4.67 mg/l, P<0.0001) and ET-1 levels (0.66 ± 0.31 vs. 0.52 ± 0.25 pg/ml, P = 0.025) in the patients were higher than in the controls, but the multivariate analysis also showed a significant difference in cholesterol level (P <0.001). There ...
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Ghorbanihaghjo et al. (2009) conducted a case-control in Age-related macular degeneration (n=93). Age-related macular degeneration vs. Apparently healthy control subjects was evaluated on Serum levels of high sensitivity C-reactive protein (hsCRP) (p=<0.0001). Age-related macular degeneration in men was associated with significantly higher serum levels of hsCRP (6.96 vs 3.64 mg/l, P<0.0001) and ET-1 (0.66 vs 0.52 pg/ml, P=0.025) compared to healthy controls.
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