Key result
Combined UVA + B radiation exposure for 4 weeks significantly increased the number of hibernoma cases in the heart tissue of female Wistar Albino rats compared with controls (P = 0.021).
Why the study?
The study was conducted to evaluate the influences of ultraviolet radiation A and B exposure on the liver and heart organs of albino rats.
Does combined UVA + B radiation exposure cause histopathological changes in the liver and heart of Wistar Albino rats?
Does combined UVA + B radiation exposure cause histopathological changes in the liver and heart of Wistar Albino rats?
p-value: p=0.021
Combined UVA and UVB radiation exposure for 4 weeks induces significant histopathological damage, including hibernomas, in the heart and liver of rats.
UVA+B exposure may damage rat heart and liver; leaves open any human clinical relevance.
This study aims to evaluate the influences of ultraviolet radiation A and B (UVA + B) exposure on the liver and heart organs of albino rats. Female Wistar Albino rats, whose hair of the dorsal skin was shaved, were exposed to a combined UVA + B radiation for 2 h/day, for 4 weeks in order to be compared with the control group. Histopathological findings in vital organs (liver and heart) were evaluated. Tissues were fixed in 10% buffered formalin (pH = 7.2) and embedded in paraffin. The histopathological findings were examined on the H&E stained sections with light microscopy. The results show that the liver and the heart were injured in the UVA + B group. Liver tissue in the UVA + B group showed minimal vacuolation, enlargement of hepatocytes and bile duct proliferation, and the heart tissue showed hibernomas; uniform large cells resembling brown fat with coarsely granular to multivacuolated cytoplasm that is eosinophilic or pale with a small central nucleus. The number of hibernoma cases was significantly higher in the UVA + B group compared with the control group (P = 0.021). The control group showed normal liver and heart histology with normal adipose tissue in the pericardium. As a result, UVA + B exposure has toxic effects, especially on the liver and the heart of Wistar albino rats. UV radiation may cause such adverse effects in humans. Therefore, protection against the harmful effects of UV radiation is of significant importance for skin and organs.
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Keskin et al. (2022) studied Ultraviolet radiation exposure. Combined UVA + B radiation vs. Control group was evaluated on Histopathological findings in vital organs (liver and heart), specifically hibernoma cases (p=0.021). Combined UVA + B radiation exposure for 4 weeks significantly increased the number of hibernoma cases in the heart tissue of female Wistar Albino rats compared with controls (P = 0.021).
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