Mathematical modeling suggests that linear couplings among cardiovascular oscillators dominate and that noise is essential for reproducing physiological synchronization and frequency variability.
Model-based support for linear couplings and noise in synchronization; leaves open validation against human cardiovascular data.
A mathematical model of the cardiovascular system is simulated numerically. The basic unit in the model is an oscillator that possesses a structural stability and robustness motivated by physiological understanding and by the analysis of measured time series. Oscillators with linear couplings are found to reproduce the main characteristic features of the experimentally obtained spectra. To explain the variability of cardiac and respiratory frequencies, however, it is essential to take into account the rest of the system, i.e. to consider the effect of noise. It is found that the addition of noise also results in epochs of synchronization, as observed experimentally. Preliminary analysis suggests that there is a mixture of linear and parametric couplings, but that the linear coupling seems to dominate.
No takes yet. Share an insight, caveat, or question.
Stefanovska et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: