Anticardiolipin activity in systemic lupus erythematosus sera is primarily due to specific anticardiolipin antibodies rather than cross-reactivity with high-avidity anti-DNA antibodies.
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Anticardiolipin activity in SLE likely reflects specific antibodies; leaves open in vivo relevance of low-avidity anti-DNA cross-reactivity.
Smeenk et al. (1987) studied this question.
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