necticut) is a fluorinated quinolone that is a broad-spectrum antibacterial agent. It is recommended for the treatment of infections caused by susceptible bacteria in lower respiratory infections, skin and skin-structure infections, bone and joint infections, urinary-tract infections, and infectious diarrhea. Recommend-ed adult dosages range from 250 mg every 12 hours (for mild urinary-tract infections) to 750 mg every 12 hours (for more severe or complicated infections). Ci-profloxacin oral tablets have been approved for mar-keting in the United States since October 1987; the drug should not be used in children or pregnant wom-en. Like other members of this drug class, the most frequent adverse reactions have involved the gastroin-testinal system (nausea, vomiting, diarrhea) or, im-
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H. A. Davis (1989) studied this question.
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