Hyaluronic acid (HA) was patterned using two soft lithographic methods on various substrates including glass, silicon dioxides, poly(hydroxyethyl methacrylate) [poly(HEMA)], polystyrene cell culture dishes, and biodegradable polylactic glycolic acid (PLGA), with no or minor chemical modification. Results indicate that HA could be used as a general platform on hydrophilic substrates for cell and protein patterning (see Figure).
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Suh et al. (2004) studied this question.
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