Why the study?
How do hypoxia and reoxygenation affect tissue ATP levels and electrical and mechanical function in isolated guinea pig ventricular muscles?
How do hypoxia and reoxygenation affect tissue ATP levels and electrical and mechanical function in isolated guinea pig ventricular muscles?
In isolated guinea pig ventricular muscles, hypoxia-induced changes in contractile force correlate with ATP depletion, whereas changes in electrical activity do not.
Contractile-ATP linkage in hypoxic guinea pig muscle but not electrical activity; hypothesis-generating and should not inform clinical ischemia management.
The myocardial ATP level in guinea pig ventricular muscles was determined during hypoxia and reoxygenation and compared with the cardiac electrical and mechanical function. The action potential duration (APD), contractile force (CF) and tissue ATP level were depressed gradually depending on the N2 concentration in the medium. Time course studies revealed that the membrane electrical activity and the ATP content did not show parallel evolution, although changes in CF coincided with changes in ATP level.
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Asano et al. (1984) studied this question.
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