Preliminary studies on the transformation of hamster embryo cells by a murine sarcoma virus are reported. Although hamster embryo cells are readily transformed by high concentrations of this virus, they are much less sensitive than are mouse embryo cells. The transformed hamster cells are spindle-shaped and stain very densely with May Grünwald-Giemsa. They grow vigorously and are easily maintained in vitro with continuous release of virus into the culture medium. The hamster grown virus shows a complex dose-response curve when assayed on mouse embryo cells. Virus-producing tumors are induced by inoculation of the hamster grown virus into newborn hamsters.
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Simons et al. (1967) studied this question.
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