Starting from a trimethylsilyl-substituted phosphine sulfide of 99:1 er (generated by n-BuLi/(-)-sparteine-mediated asymmetric lithiation of a dimethylphosphine sulfide), a two-step process of regioselective lithiation-trapping and silyl group removal has been used to prepare a range of P-stereogenic compounds, including precursors to diphosphine ligands (e.g., Mini-PHOS). This two-step protocol delivers products with the opposite configuration to that obtained by direct asymmetric lithiation-trapping of a dimethylphosphine sulfide using n-BuLi/(-)-sparteine.
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Gammon et al. (2009) studied this question.
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