Bioactive Glass Granules for Regeneration of Human Periodontal Defects

Purpose: A comparative study which evaluated the effectiveness of bioactive glass granules of uniform size (300–335 μm) for the regenerative treatment of interproximal intrabony periodontal defects was conducted. Materials and Methods: Twelve pairs of advanced periodontal lesions in 12 patients (6 males and 6 females) were treated in a split‐mouth design with open flap débridement in the control sites and open flap debridement with bioactive glass particles placed in the test sites. Results: At 6 months post‐treatment, both treatment modalities demonstrated a gain in clinical attachment level (CAL), with the test sites having a significantly (p < .01) greater gain in CAL than the control sites. Reentry procedures were performed to assess the amount of hard tissue fill. The test sites demonstrated significantly (p < .001) more gain in hard tissue fill than the controls. CLINICAL SIGNIFICANCE The use of bioactive glass granules of uniform size in human interproximal intrabony periodontal defects resulted in significantly better hard tissue fill and clinical attachment gain than surgical debridement alone.