Aldosterone Secretion and Various Forms of Hypertensive Vascular Disease

Editorials1 July 1963Aldosterone Secretion and Various Forms of Hypertensive Vascular DiseaseJOHN H. LARAGH, M.D., PAUL J. CANNON, M.D., RICHARD P. AMES, M.D.JOHN H. LARAGH, M.D., PAUL J. CANNON, M.D., RICHARD P. AMES, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-1-117 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo papers in this issue of the ANNALS highlight the growing interest and increasing state of our knowledge about the role of the kidney and of the adrenal cortex in the pathogenesis of certain, possibly common, forms of hypertensive disease. These studies re-emphasize that, at least in patients with hypertension, the kidney may elaborate substance which stimulates secretion of the sodium-retaining hormone, aldosterone.In the paper by Itskovitz and coworkers, further observations are described on the morphology of the juxtaglomerular apparatus of the kidney in patients with arterial hypertension. The paper by Goldberg and McCurdy presents a detailed metabolic study...References1. GOLDBLATT H: Renal Origin of Hypertension, Charles C Thomas, Springfield, Illinois, 1948. Google Scholar2. GOORMAGHTIGH N: Existence of an endocrine gland in the media of the renal arterioles. Proc. Soc. Exp. Biol. Med. 42: 688, 1939. CrossrefGoogle Scholar3. GOORMAGHTIGH N: La fonction endocrine des arterioles renales. Libraire Fonteyn, Louvain, 1944. Google Scholar4. TOBIAN L: Interrelationships of electrolytes juxtaglomerular cells and hypertension. Physiol. Rev. 40: 280, 1960. CrossrefMedlineGoogle Scholar5. GROSS F: Renin und Hypertensin physiologische oder pathologische Wirkstoffe? Klin. Wschr. 36: 693, 1958. CrossrefMedlineGoogle Scholar6. LARAGHULICKJANUSZEWICZDEMINGKELLYLIEBERMAN JHSUVQBWCS: Aldosterone secretion and primary and malignant hypertension. J. Clin. Invest. 39: 1091, 1960. CrossrefMedlineGoogle Scholar7. LARAGHANGERSKELLYLIEBERMAN JHMWGS: Hypotensive agents and pressor substances. The effect of epinephrine, norepinephrine, angiotensin II and others on the secretory rate of aldosterone in man. Ibid., 230. Google Scholar8. LARAGH JH: The role of aldosterone in man: evidence for regulation of electrolyte balance and arterial pressure by a renal-adrenal system which may be involved in malignant hypertension. JAMA 174: 293, 1960. CrossrefMedlineGoogle Scholar9. CARPENTERDAVISAYERS CCJOCR: Relation of renin, angiotensin II, and experimental renal hypertension due to aldosterone secretion. Ibid., 2026. Google Scholar10. BIRONKOIWNOWACZYNSKIBROUILLETGENEST PEWJJ: The effects of intravenous infusions of valine-5 angiotensin II and other pressor agents on urinary electrolytes and corticosteroids, including aldosterone. J. Clin. Invest. 40: 338, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: College of Physicians and Surgeons Columbia University The Presbyterian Hospital New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLow-renin status in therapy-resistant hypertensionComment peut évoluer la prise en charge de l'hypertension artérielleRenin–Angiotensin–Aldosterone System and the Renal Regulation of Sodium, Potassium, and Blood Pressure HomeostasisA Bipolar Analysis of Blood Pressure Phenomena: The Vasoconstriction and Volume Factors in Normotension and in the Spectrum of Hypertensive Disorders as Revealed by Renin-Sodium Profiling or Pharmacologic Probes; Prorenin as a Determinant of Renin SecretionRenin, Renin Inhibition and Antihypertensive TherapyThe Renin System for Understanding Human Hypertension: Evidence for Blood Pressure Control by A Bipolar Vasoconstriction-Volume Mechanism. Prorenin as a Determinant of Renin SecretionAcute and long-term studies of the mechanisms of action of beta-blocking drugs in lowering blood pressureRenin-angiotensin-aldosterone system in long-term renal transplant patientsSplanchnic blood flow in essential hypertension and in hypertensive patients with renal artery stenosis.Radioimmunologische Methode zur Aldosteronbestimmung im UrinVasoconstriction-volume analysis for understanding and treating hypertension: The use of renin and aldosterone profilesRenin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular diseaseAldosterone, Deoxycorticosterone, and Corticosterone Metabolism in Benign Essential HypertensionRenin and Aldosterone in the Etiology and Prognosis of Essential Hypertension: Their Relation to Vascular ComplicationsPlasmareninaktivit�t bei Hypertonien unter Stimulations- und SuppressionsbedingungenSuppressed Plasma Renin Activity in Essential Hypertension Roles of Plasma Volume, Blood Pressure, and Sympathetic Nervous SystemAUREA JOSE, M.D., J. RICHARD CROUT, M.D., F.A.C.P., NORMAN M. KAPLAN, M.D., F.A.C.P.PLASMA ELECTROLYTES, RENIN, AND ALDOSTERONE IN THE DIAGNOSIS OF PRIMARY HYPERALDOSTERONISMControl of Aldosterone SecretionRenal vascular hypertension, further experiencesRenin Content of the Kidney in Primary AldosteronismRenin and angiotensin. A survey of some aspects.Diagnostic significance of humoral factors in renovascular hypertensionThe activity of the renin-angiotensin-aldosterone system in hypertensive and hydropic diseasesPLASMA-RENIN AND ALDOSTERONE SECRETION IN HYPERTENSIVE PATIENTS WITH RENAL OR RENAL ARTERY LESIONS 1 July 1963Volume 59, Issue 1_Part_1Page: 117-120KeywordsAdrenal cortexAldosteroneHormonesHypertensionKidneysPathogenesisRenal diseasesVascular diseases Issue Published: 1 July 1963 PDF DownloadLoading ...