The Fat Overload Syndrome: Successful Treatment with Plasma Exchange

Brief Reports1 April 1990The Fat Overload Syndrome: Successful Treatment with Plasma ExchangeMarin H. Kollef, MD, Michael T. McCormack, MD, William E. Caras, MD, Vishnu V.B. Reddy, MD, David Bacon, MDMarin H. Kollef, MD, Michael T. McCormack, MD, William E. Caras, MD, Vishnu V.B. Reddy, MD, David Bacon, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-7-545 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe fat overload syndrome is a rare complication of the intravenous administration of fat emulsion. It is characterized by sudden elevation of the serum triglyceride level associated with fever, hepatosplenomegaly, coagulopathy, and variable end-organ dysfunction (1-3). Specific successful therapy other than supportive care for the fat overload syndrome has not been described. We report the first successful use of plasma exchange in treating this condition.Case ReportA 39-year-old man was admitted to a community hospital for an exacerbation of his long-standing asthma. He was treated with intravenous theophylline, erythromycin, and nebulized metaproterenol. On the second hospital day, supplemental parenteral...References1. HeymanStorchAment MSM. The fat overload syndrome. Report of a case and literature review. Am J Dis Child. 1981;135:628-30. CrossrefMedlineGoogle Scholar2. BelinBivinsJonaYoung RBJV. Fat overload with a 10% soybean oil emulsion. Arch Surg. 1976;111:1391-3. CrossrefMedlineGoogle Scholar3. TaylorBuckner RC. Fat overload from a 10 percent soybean oil emulsion in a marrow tansplant recipient. West J Med. 1982;136:345-9. MedlineGoogle Scholar4. HaberHawkinsSeilheimerSaleem LEDA. Fat overload syndrome. An autopsy study with evaluation of the coagulopathy. Am J Clin Pathol. 1988;90:223-7. CrossrefMedlineGoogle Scholar5. HessovMelsonHaug IFA. Postmorten findings in three patients treated with intravenous fat emulsions. Arch Surg. 1979;114:66-8. CrossrefMedlineGoogle Scholar6. LequireShapiroLequire VJC. A study of the pathogenesis of fat embolism based on human necropsy material and animal experiments. Am J Pathol. 1959;35:999-1015. MedlineGoogle Scholar7. WenzBarland BP. Therapeutic intensive plasmapheresis. Semin Hematol. 1981;18:147-62. MedlineGoogle Scholar8. CohenAmbinderWolkeFieldSchaffner LEASF. Role of plasmapheresis in primary biliary cirrhosis. Gut. 1985;26:291-4. CrossrefMedlineGoogle Scholar9. BergerMillerBonniciJoffeDubovsky GJFHD. Continuous flow plasma exchange in the treatment of homozygous familial hypercholesterolemia. Am J Med. 1978;65:243-51. CrossrefMedlineGoogle Scholar10. BetteridgeBakowskiTaylorRecklessDe SilvaGalton DMKJSD. Treatment of severe diabetic hypertriglyceridaemia by plasma exchange [Letter]. Lancet. 1978;1:1368. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Fitzsimons Army Medical Center, Aurora, Colorado. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByASPEN lipid injectable emulsion safety recommendations part 2: Neonate and pediatric considerationsPopulation Semiphysiologic Kinetic Modeling and Simulation of Plasma Triglyceride Levels After Soybean Oil–Based Intravenous Lipid Emulsion Administration in RatsIntravenous Fat Emulsion Formulations for the Adult and Pediatric PatientSyndrome de surcharge en lipides : un accident iatrogène rareAccidental Bolus of Parenteral NutritionParenteral nutritionFat Overload Syndrome After the Rapid Infusion of SMOFlipid EmulsionDiagnosis and Management of Fat Overload Syndrome in an Elderly ManProlonged lipemia and pancreatitis due to extended infusion of lipid emulsion in bupropion overdoseRapid Infusion of Fish Oil–Based Emulsion in Infants Does Not Appear to be Associated With Fat Overload SyndromeENDOCRINE AND METABOLIC ADVERSE EFFECTS OF NON-HORMONAL AND NON-METABOLIC DRUGSNitric oxide involvement in lipid emulsion-induced vascular pain in anesthetized ratsPancreatitis and hypertriglyceridaemiaParenteral nutritionInvited Review: Lipoprotein Lipase and Triglyceride-Rich Lipoprotein MetabolismSerum triglycerides, the liver and the pancreasMetabolic and nutritional considerations in nonalcoholic fatty liverOverdose of Intravenous Fat Emulsion in a Preterm Infant: Case ReportPhysicochemical assessment of total nutrient admixture stability and safety: Quantifying the riskPlasma Exchange for Non-Renal IndicationsIntravenous and parenteral infusions 1 April 1990Volume 112, Issue 7Page: 545-546KeywordsAsthmaBlood plasmaCoagulopathyErythromycinFatsFeversHepatosplenomegalyMedical intensive care unitsPulmonary diseasesSerum triglycerides Issue Published: 1 April 1990 PDF DownloadLoading ...