Key result
In patients with type 2 diabetes, poor glycemic control during a 7.5-year follow-up was strongly associated with the development of cardiovascular autonomic dysfunction (OR 2.984 for mean A1C ≥9.0% vs ≤7.0%).
Why the study?
Is glycemic control status associated with the progression of cardiovascular autonomic dysfunction in patients with type 2 diabetes?
Cohort (n=783)
No
Is glycemic control status associated with the progression of cardiovascular autonomic dysfunction in patients with type 2 diabetes?
Poor glycemic control over time is strongly associated with the development of cardiovascular autonomic dysfunction in patients with type 2 diabetes.
Answers are grounded in this paper and cite their sources.
Poor glycemic control may heighten autonomic dysfunction risk in type 2 diabetes; leaves open whether intensification prevents progression.
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Ko et al. (2008) conducted a cohort in Type 2 diabetes with initially normal cardiovascular autonomic nervous function (n=783). Mean A1C level ≥9.0% vs. Mean A1C ≤7.0% was evaluated on Development of cardiovascular autonomic dysfunction (OR 2.984, 95% CI 1.177-7.561, p=0.021). In patients with type 2 diabetes, poor glycemic control during a 7.5-year follow-up was strongly associated with the development of cardiovascular autonomic dysfunction (OR 2.984 for mean A1C ≥9.0% vs ≤7.0%).
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