Key result
Predialysis hypotension was not associated with 12-, 24-, and 36-month mortality, whereas diabetes (P=0.011), anuria (P=0.004), male sex (P=0.029), and age (P<0.001) predicted higher mortality.
Why the study?
Does predialysis hypotension predict mortality in patients on maintenance hemodialysis?
Observational (n=866)
No
Does predialysis hypotension predict mortality in patients on maintenance hemodialysis?
Predialysis hypotension does not appear to be an independent predictor of 12- to 36-month mortality in maintenance hemodialysis patients, particularly those without diabetes and with adequate dialysis.
Answers are grounded in this paper and cite their sources.
Predialysis hypotension should not yet prompt targeted interventions to reduce mortality in hemodialysis; leaves open its role in other outcomes or subgroups.
INTRODUCTION: Predialysis hypotension has been noted to be a predictor of mortality in hemodialysis (HD) patients. Previous studies evaluating the impact of predialysis hypotension on the mortality of HD patients did not exclude patients with diabetes mellitus (DM) or cardiovascular disease. METHODS: Eight hundred and sixty-six patients on maintenance HD were recruited. Clinical parameters were recorded and subjected to the analysis of predictors of predialysis hypotension and mortality. RESULTS: Multivariate logistic regression analyses indicated that DM (odds ratio [OR]: 0.439, P=0.002), hypertension history (OR: 0.634, P=0.022), Kt/V Daugirdas (OR: 2.545, P=0.001), anuria (OR: 2.313, P=0.002), serum phosphate (OR: 0.833, P=0.010), and serum triglyceride (OR: 1.002, P=0.012) were associated with predialysis hypotension. Multivariate Cox regression analysis showed that age (P<0.001), male sex (P=0.029), anuria (P=0.004), and DM (P=0.011) were associated with higher probability of 24- and 36-month mortality. Predialysis hypotension was not associated with higher probability of 12-, 24-, and 36-month mortality. CONCLUSION: Predialysis hypotension is not a predictor of 12-, 24-, and 36-month survival in patients without DM and with higher dialysis adequacy.
No takes yet. Share an insight, caveat, or question.
Weng et al. (2016) conducted an observational in maintenance hemodialysis (n=866). Predialysis hypotension vs. No predialysis hypotension was evaluated on 12-, 24-, and 36-month mortality. Predialysis hypotension was not associated with 12-, 24-, and 36-month mortality, whereas diabetes (P=0.011), anuria (P=0.004), male sex (P=0.029), and age (P<0.001) predicted higher mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: