Key result
Loss of T6BP and NDP52 in RNAi knockdown cells reduced membrane ruffling activity, increased stress fibre and focal adhesion formation, and upregulated constitutive secretion of alkaline phosphatase.
T6BP and NDP52 interact with myosin VI to regulate membrane trafficking, cell adhesion, and cytokine-dependent cell signaling.
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Knockdown effects on ruffling, adhesions, and secretion are preliminary; leaves open T6BP/NDP52 roles in cardiovascular cell biology.
Morriswood et al. (2007) studied this question. RNAi knockdown of T6BP and NDP52 was evaluated on Membrane ruffling activity, stress fibre and focal adhesion formation, and constitutive secretion of alkaline phosphatase. Loss of T6BP and NDP52 in RNAi knockdown cells reduced membrane ruffling activity, increased stress fibre and focal adhesion formation, and upregulated constitutive secretion of alkaline phosphatase.
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