Key result
Myocardial nuclear staining for DNA damage markers PAR and γ-H2A.X was an independent prognostic factor for left ventricular reverse remodeling in patients with dilated cardiomyopathy.
Why the study?
Does myocardial nuclear staining for DNA damage markers predict left ventricular reverse remodeling in patients with dilated cardiomyopathy?
Observational (n=58)
Does myocardial nuclear staining for DNA damage markers predict left ventricular reverse remodeling in patients with dilated cardiomyopathy?
Quantification of DNA damage markers PAR and γ-H2A.X in myocardial biopsies can serve as a novel prognostic predictor for left ventricular reverse remodeling in patients with dilated cardiomyopathy.
Biopsy DNA damage markers may predict LVRR in DCM; hypothesis-generating and requires validation before clinical use.
This study evaluated myocardial nuclear staining for the DNA damage markers poly(ADP-ribose) (PAR) and γ-H2A.X in 58 patients with dilated cardiomyopathy. Patients with left ventricular reverse remodeling (LVRR) showed a significantly smaller proportion of PAR-positive nuclei and γ-H2A.X-positive nuclei in biopsy specimens compared with those without LVRR. Propensity analysis showed that the proportion of both PAR-positive and γ-H2A.X-positive nuclei were independent prognostic factors for LVRR. In conclusion, we showed the utility of DNA damage-marker staining to predict the probability of LVRR, thus revealing a novel prognostic predictor of medical therapy for dilated cardiomyopathy.
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Ko et al. (2019) conducted an observational in Dilated cardiomyopathy (n=58). Myocardial nuclear staining for DNA damage markers PAR and γ-H2A.X was evaluated on Left ventricular reverse remodeling (LVRR). Myocardial nuclear staining for DNA damage markers PAR and γ-H2A.X was an independent prognostic factor for left ventricular reverse remodeling in patients with dilated cardiomyopathy.
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