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A New Synthesis of DL‐Armentomycin and Related 2‐Amino‐4‐polyhalobutyric Acids An efficient method for the synthesis of 2‐amino‐4‐halobutyric acids 2 starting from the corresponding ethyl 2,4‐polyhalobutyrates 1 is presented (s. Scheme 1). The method is illustrated by a high yield synthesis of the known antibiotic DL‐armentomycin (= 2‐amino‐4,4‐dichlorobutyric acid; 2a).
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Heinzer et al. (1981) studied this question.
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