Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

Antonella Messore; Angela Corona; Valentina Noemi Madia; Francesco Saccoliti; Valeria Tudino; Alessandro De Leo; Davide Ialongo; Luigi Scipione; Daniela De Vita; Giorgio Amendola; Ettore Novellino; Sandro Cosconati; Mathieu Métifiot; Marie‐Line Andréola; Francesca Esposito; Nicole Grandi; Enzo Tramontano; Roberta Costi; Roberto Di Santo

doi:10.1021/acs.jmedchem.1c00535

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Abstract

cofactor and interact with amino acids of the RNase H domain that are highly conserved among naïve and treatment-experienced patients. In general, the new inhibitors influenced also the polymerase activity of RT but were selective against RNase H vs the IN enzyme.

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Messore et al. (2021) studied this question.

synapsesocial.com/papers/6a990b728274c2559e3629cf https://doi.org/10.1021/acs.jmedchem.1c00535

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Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

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Abstract

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Cite This Study

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

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Abstract

Discussion

Cite This Study

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