A Comparative Study of Efficacy of Topical Difluprednate Ophthalmic Emulsion 0.05% Eyedrops With Betamethasone Suspension 0.1% in Postoperative Small Incision Cataract Surgery

Postoperative operative inflammation following cataract surgery is common occurrence may be due to several surgery-dependent factors such as surgical trauma, intraocular lens type, and due to various physical, chemical and biological agents introduced during surgery and also on patient-dependent factors such as history of inflammatory disease and degree of iris pigmentation. Anti-inflammatory agents are routinely prescribed following cataract extraction surgery to resolve signs and symptoms of inflammation more rapidly and to improve patient comfort. For the treatment of postoperative ocular inflammation and pain the most widely prescribed topical corticosteroid is betamethasone 0.1%, and Difluprednate ophthalmic emulsion 0.05% a strong topical steroid. Hence, this study was to compare the efficacy and safety of topical corticosteroids-Difluprednate 0.05% and betamethasone 0.1%, in managing inflammation and pain following post cataract extraction surgery. In a total 100 patients were randomized into two groups Group -A (50 patients) prescribing topical Difluprednate emulsion 0.05% and Group-B (50 patients) prescribing betamethasone phosphate 0.1%. in our observation after 15 days no pain in group-A, after 30 days no one are having corneal oedema in group-A. Difluprednate emulsion 0.05% drug was efficient in the reduction of anterior chamber cells and flare with betamethasone phosphate 0.1% being more rapid. Based on our findings and previous study results, Difluprednate emulsion 0.05% can be used in post-operative management post cataract surgery, however, further clinical trials with long follow-up periods are required.