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The first prerequisite for an optimum effect of photodynamic therapy with chlorophyll-derived photosensitizers is irradiation at the S1 absorption maximum in the red spectral region. This absorption maximum changes its position due to molecular association by 20 to 100 nm depending on the subcellular environment, and must be determined by direct absorption spectrometry in the region of subcellular sensitizer localization. Fluorescence-intensifying video microscopy allows for localization of the sensitizer storage site at or near the Golgi apparatus of OAT 75 small-cell lung carcinoma cells. The absorption maximum at 760 nm taken from spectra of single cells and cell layers determines the postulated optimum condition for dye laser irradiation with bacteriopheophorbide a methyl ester as the sensitizer.
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Joerg G. Moser (1992) studied this question.
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