The synthesis of various diastereoisomeric (±) H4a,H9a‐trans,H9,H9a‐cis‐ (VIII) and H4a,H9a‐trans, H9,H9a‐trans‐2,3,4,4a,9,9a‐hexahydro‐9‐phenyl‐1H‐indeno[1,2‐b]pyrazines (IX) is described, using as key step for piperazine ring formation an alkoxyphosphonium salt. CompoundIXawas prepared as a putative serotonin reuptake inhibitor.
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Chahboun et al. (1995) studied this question.
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